Cd81 Cd81 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd81provided by RGD
Official Full Name: Cd81 moleculeprovided by RGD
Primary source: RGD:2315
See related: AllianceGenome:RGD:2315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tapa1
Summary: Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in regulation of cell population proliferation; regulation of growth; and response to wounding. Located in apical plasma membrane. Is integral component of membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 1836.2), Heart (RPKM 1738.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41-q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207665274..207681094)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198235861..198251660)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216237663..216253460)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Title: Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Expression and functions of cluster of differentiation 9 and 81 in rat mammary epithelial cells.
Title: Expression and functions of cluster of differentiation 9 and 81 in rat mammary epithelial cells.
Overexpression of CD81 in pregnant rats triggers preeclampsia-like manifestations in vivo.
Title: Up-regulation of CD81 inhibits cytotrophoblast invasion and mediates maternal endothelial cell dysfunction in preeclampsia.
These findings strongly suggest that CD63 and CD81 play an important role in Schwann cell spreading along axons but seem to be dispensable for Schwann cell myelination
Title: Tetraspanins are involved in Schwann cell-axon interaction.
CD81 exerts significant inhibitory effect, dose-dependently and time-dependently, on the proliferation of astrocytes
Title: CD81 inhibits the proliferation of astrocytes by inducing G(0)/G (1) arrest in vitro.
Data suggest that CD81 does not function as a binding receptor by itself but promotes photoreceptor outer segment particle binding through functional interaction specifically with alpha v beta5 integrin.
Title: Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
During spermatogenic cell apoptosis, integrin beta1, alpha3, and alpha6 subunits, and tetraspanins CD9 and C81 become displaced away from the developing apoptotic bodies.
Title: Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells.
Induction of CD81 expression through HDAC inhibition is a novel strategy to promote growth arrest in glioma cells.
Title: CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.
CD81 is temporally up-regulated after injury to the retina.
Title: Temporal regulation of CD81 following retinal injury in the rat.
results support the hypothesis that CD81 is associated with final stages of retinal pigment epithelium cell maturation, establishing key molecular interactions linking cell membrane proteins into macromolecular complexes containing PDZ protein scaffolds
Title: The developmental regulation of CD81 in the rat retina.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94618 (e-PCR)
- UniSTS:119866

RH127728 (e-PCR)
- UniSTS:211038

Cd81 (e-PCR), detects polymorphism
- UniSTS:532164

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class II protein binding	IEA Inferred from Electronic Annotation more info
enables MHC class II protein binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor binding	IEA Inferred from Electronic Annotation more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell costimulation	IEA Inferred from Electronic Annotation more info
involved_in CD4-positive, alpha-beta T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in CD4-positive, alpha-beta T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in immunological synapse formation	IEA Inferred from Electronic Annotation more info
involved_in immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in immunological synapse formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage fusion	IEA Inferred from Electronic Annotation more info
involved_in macrophage fusion	ISO Inferred from Sequence Orthology more info
involved_in macrophage fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast fusion involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion involved in skeletal muscle regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoclast fusion	ISO Inferred from Sequence Orthology more info
involved_in osteoclast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of adaptive immune memory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response to antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process in the vacuole	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process in the vacuole	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein exit from endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein exit from endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in tetraspanin-enriched microdomain	IEA Inferred from Electronic Annotation more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD81 antigen

Names: CD 81 antigen; CD81 antigen (target of antiproliferative antibody 1); target of the antiproliferative antibody 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.